M2 SSD in enclosure

Will an M2 SSD in an external USB enclosure present a 4096 block size to Winclone, thereby allowing a direct migration of Bootcamp to the external drive which would then be bootable?

Typically, a USB enclosures presents a 4096 block size as 512. I would recommend not doing a volume to volume clone but rather saving a WIM-based image and then restoring.